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KMID : 0043320100330121943
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Archives of Pharmacal Research
2010 Volume.33 No. 12 p.1943 ~ p.1951
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Biological activities of fructus arctii fermented with the basidiomycete Grifola frondosa
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Kim Jin-Hwa
Bae Jun-Tae
Song Min-Hyeon
Lee Geun-Su
Choe Soo-Young
Pyo Hyeong-Bae
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Abstract
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Fructus arctii extract containing phenolic glycosides was cultured with Grifola frondosa mycelia to produce β-glucosidase and its biological activities were studied. This β-glucosidase converted the glycosides (arctiin and caffeic acid derivatives) into aglycones (arctigenin and caffeic acid). Fermented Fructus arctii extract (G-FAE) with G. frondosa had antioxidant and 5-lipoxygenase inhibitory activities. The photoprotective potential of G-FAE was tested in human dermal fibroblasts (HDF) exposed to ultra-violet A (UVA). It was revealed that G-FAE had an inhibitory effect on human interstitial collagenase (matrix metalloproteinase, MMP-1) expression in UVA-irradiated HDF. The treatment of UVA-irradiated HDF with G-FAE resulted in a dose-dependent decrease in the expression level of MMP-1 mRNA. G-FAE also showed notable stimulation of collagen biosynthetic activity for fibroblasts. These diverse functionalities suggest that G-FAE could be a promising cosmetic ingredient.
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KEYWORD
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Fructus arctii, Grifola frondosa, β-Glucosidase, Antioxidant, Matrix metalloproteinase-1, Collagen
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